To sence or not to sence – New insights from GPCR and arrestin biosensors |
2019 |
Haider, R. S., Goodbole, A., and Hoffmann, C. |
Curr Opin Cell Biol |
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Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1 |
2019 |
Harnoš, J., Cañizal, M. C. A., Jurásek, M., Kumar, J., Holler, C., Schambony, A., Hanáková, K., Bernatík, O., Zdráhal, Z., Gömöryová, K., Gybeľ, T., Radaszkiewicz, T. W., Kravec, M., Trantírek, L., Ryneš, J., Dave, Z., Fernández-Llamazares, A. I., Vácha, R., Tripsianes, K., Hoffmann, C., and Bryja, V. |
Nature Communication |
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Intramolecular and Intermolecular FRET Sensors for GPCRs – Monitoring Conformational Changes and Beyond |
2018 |
Kauk M., and Hoffmann, C. |
Trends in Pharmacological Sciences |
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Lack of beta-arrestin signaling in the absence of active G proteins |
2018 |
Grundmann, M., Merten, N., Malfacini, D., Inoue, A., Preis, P., Simon, K., Rüttiger, N., Ziegler, N., Benkel, T., Schmitt, N.K., Ishida, S., Müller, I., Reher, R., Kawakami, K., Inoue, A., Rick, U., Kühl, T., Imhof, D., Aoki, J., König, G.M., Hoffmann, C., Gomeza, J., Wess, J., Kostenis, E. |
Nature Communications |
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FZD5 is a Gaq-coupled receptor exhibiting the functional hallmarks of proto-typical GPCRs |
2018 |
Wright, S.C., Alonso Canizal, M.C., Benkel, T., Simon, K., Le Gouill, C., Matricon, P., Namkung, Y., Lukasheva, V., König, G.M., Laporte, S.A., Carlsson, J., Kostenis, E., Bouvier, M., Schulte, G., Hoffmann, C. |
Sci Signal |
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beta-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle |
2016 |
Nuber, S., Zabel, U., Lorenz, K., Nuber, A., Milligan, G., tobin, A. B., Lohse, M. J., and Hoffmann, C. |
Nature |
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Optical probes based on G protein-coupled receptors - added work or added value? |
2016 |
Stumpf, A.D.; Hoffmann, C. |
Br J Pharm |
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Ligand residence time at G protein-coupled receptors-Why we should take our time to study it |
2015 |
Hoffmann, C., Castro, M., Rinken, A., Leurs, R., Hill, S. J., and Vischer, H. F. |
Mol Pharmacol |
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Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor |
2014 |
Bock, A., Chirinda, B., Krebs, F., Messerer, R., Bätz, J., Muth, M., Dallanoce, C., Klingenthal, D., Tränkle, C., Hoffmann, C., De Amici, M., Holzgrabe, U., Kostenis, E., and Mohr, K. |
Nat Chem Biol |
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The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling |
2012 |
Bock, A., Merten, N., Schrage, R., Dallanoce, C., Bätz, J., Klöckner, J., Schmitz, J., Matera, C., Simon, K., Kebig, A., Peters, L., Muller, A., Schrobang-Ley, J., Tränkle, C., Hoffmann, C., De Amici, M., Holzgrabe, U., Kostenis, E., and Mohr, K. |
Nat Commun |
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Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1 |
2012 |
Hlavackova, V., Zabel, U., Frankova, D., Bätz, J., Hoffmann, C., Prezeau, L., Pin, J. P., Blahos, J., and Lohse, M. J. |
Sci Signal |
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Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling |
2012 |
Lohse, M.J., Nuber, S., and Hoffmann C. |
Pharmacol Rev |
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Comparison of the activation kinetics of the m3 acetylcholine receptor and a constitutively active mutant receptor in living cells |
2012 |
Hoffmann, C., Nuber, S., Zabel, U., Ziegler, N., Winkler, C., Hein, P., Berlot, C. H., Bünemann, M., and Lohse, M. J. |
Mol Pharmacol |
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Fluorescent labeling of tetracysteine-tagged proteins in intact cells |
2010 |
Hoffmann, C., Gaietta, G., Zürn, A., Adams, S. R., Terrillon, S., Ellisman, M. H., Tsien, R. Y., and Lohse, |
Nat Protoc |
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Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores |
2010 |
Zürn, A., Klenk, C., Zabel, U., Reiner, S., Lohse, M. J., and Hoffmann, C. |
Bioconjug Chem |
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Fluorescence Resonance Energy Transfer Analysis of {alpha}2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes |
2009 |
Zürn, A., Zabel, U., Vilardaga, J. P., Schindelin, H., Lohse, M. J., and Hoffmann, C. |
Mol Pharmacol |
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Molecular Basis of Partial Agonism at the Neurotransmitter {alpha}2A-Adrenergic Receptor and Gi-protein Heterotrimer |
2006 |
Nikolaev, V. O., Hoffmann, C., Bünemann, M., Lohse, M. J., and Vilardaga, J. P. |
J Biol Chem |
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A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells |
2005 |
Hoffmann, C., Gaietta, G., Bünemann, M., Adams, S. R., Oberdorff-Maass, S., Behr, B., Vilardaga, J. P., Tsien, R. Y., Ellisman, M. H., and Lohse, M. J. |
Nat Methods |
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